A semi-trailer southbound on Road 117 West was slowing down to turn west into a driveway when it was struck from behind by a van.
The 59-year-old male driver of the semi-trailer, from the RM of Riverdale was not injured.
The 31-year-old male driver of the van, from Brandon, was deceased on scene.
Alcohol and seatbelts are not considered factors in this collision.
A RCMP Forensic Collision Reconstructionist is assisting with the ongoing investigation.